How long does NPH insulin typically last?

NPH insulin, or Neutral Protamine Hagedorn insulin, is an intermediate-acting insulin commonly used in diabetes management. Its duration of action typically ranges from 10 to 20 hours, with a peak effect occurring approximately 4 to 12 hours after administration.

The option that states it lasts for 24+ hours is an overestimation of NPH’s action. NPH is often administered to provide a background level of insulin that can facilitate glycemic control throughout much of the day, but it is not effective for a full 24 hours. Instead, its practical utility is seen in covering needs for a typical day, which aligns more closely with the duration provided by the choice that reflects 12-16 hours or likely the 18-24 hours range which is still within the commonly accepted range for intermediate-acting insulins.

This understanding is critical for healthcare professionals to ensure accurate dosing schedules and to avoid potential hypoglycemic events that could arise from miscalculating the duration of insulin activity.