True or False: Dehydration can lead to anti-infectives reaching toxic levels.

Dehydration can indeed lead to anti-infectives reaching toxic levels due to the changes in the body's fluid balance and the way medications are metabolized and excreted. When a person is dehydrated, there is a reduced volume of fluids in the body, which can shrink the kidney's filtering capacity and slow down the elimination of drugs from the system. This can result in higher concentrations of medications in the bloodstream, potentially leading to toxicity, especially with anti-infectives that have narrow therapeutic windows or are reliant on kidney function for clearance. Therefore, recognizing the connection between dehydration and the risk of toxicity is crucial in medication management, emphasizing the importance of maintaining proper hydration, particularly when administering various medications.