What cardiovascular signs may indicate an overdose of serotonin reuptake inhibitors?

Tachycardia and hypotension are common cardiovascular signs associated with an overdose of serotonin reuptake inhibitors (SRIs), such as selective serotonin reuptake inhibitors (SSRIs). When there's an excess of serotonin in the central nervous system, it can lead to overstimulation of the cardiovascular system. This stimulation often results in an increase in heart rate (tachycardia) as the body attempts to cope with the heightened serotonin levels. At the same time, hypotension can occur due to various factors, including increased peripheral vasodilation or alterations in vascular tone.

These two symptoms together indicate how the cardiovascular system responds to an overdose, highlighting the need for careful monitoring in individuals using these medications, especially when dosage changes or new medications are introduced. Understanding these signs can aid healthcare professionals in identifying potential complications related to serotonin reuptake inhibitor overdose and initiating appropriate interventions.