What is a primary concern when a patient is on high-dose steroid therapy?

Fluid retention is a significant concern when a patient is on high-dose steroid therapy because corticosteroids can affect the body's regulation of sodium and water. These medications can cause sodium retention and, subsequently, an increase in fluid volume in the body, which may lead to edema and hypertension. In situations of high-dose therapy, the risk of such side effects is heightened, and clinicians often monitor patients for fluid status and associated complications.

In addition, while psychological effects, gastrointestinal upset, and joint pain can also occur with steroid use, fluid retention tends to present more immediate health concerns. It can exacerbate conditions like heart failure and can significantly impact other organ systems, making fluid management a priority in patients undergoing high-dose steroid treatments. Understanding the potential for fluid retention helps healthcare providers anticipate and mitigate risks associated with steroid therapy.