What is a severe adverse effect of macrolides?

Hepatotoxicity is considered a severe adverse effect of macrolides. This class of antibiotics, which includes drugs like erythromycin and azithromycin, is known to sometimes cause liver damage when used, particularly in patients with preexisting liver conditions or when used in conjunction with other medications that affect liver function. Hepatotoxicity can manifest as elevated liver enzymes, jaundice, or, in rare cases, more serious liver injury, emphasizing the need for careful monitoring of liver function in patients receiving these medications.

Other potential side effects of macrolides, such as skin rash or gastrointestinal disturbances, are typically less severe compared to hepatotoxicity. Weight gain is not commonly associated with macrolides and hypertension is generally unrelated to their use. Therefore, hepatotoxicity stands out as a serious concern in the clinical use of macrolides.