What is the most common allergy related to anti-infective agents?

The most common allergy related to anti-infective agents is indeed associated with penicillin. This antibiotic is widely used and has been on the market for many years, leading to a larger population of patients who may have developed an allergy to it. Penicillin allergy can manifest in various ways, including skin rashes, hives, and, in more severe cases, anaphylaxis.

Due to its extensive use and the historical prevalence of allergic reactions recorded in clinical practice and studies, penicillin stands out as the most commonly reported allergy in medical literature. The immune response to penicillin can also lead to cross-reactivity with other beta-lactam antibiotics, such as certain cephalosporins, but the fundamental issue remains that penicillin itself is the most frequently identified trigger for allergic reactions among anti-infective agents.