What serious side effect is associated with Aminoglycosides?

Aminoglycosides are a class of antibiotics commonly used to treat serious infections caused by Gram-negative bacteria. One of the serious side effects associated with this class of drugs is nephrotoxicity, which refers to kidney damage. This side effect is particularly notable because it can lead to acute kidney injury, which may necessitate close monitoring of kidney function during treatment.

The mechanism by which aminoglycosides cause nephrotoxicity involves their accumulation in renal tubular cells, leading to cellular damage and dysfunction. Clinicians often monitor patients' serum creatinine levels and urine output during therapy to detect any changes in kidney function early.

Other side effects from aminoglycosides can include ototoxicity (hearing loss) and potential vestibular disturbances, but these are not listed as options here. Nephrotoxicity remains a critical concern, especially in patients with pre-existing renal impairment or those receiving high doses over prolonged periods.