What should NSAIDs be taken with to minimize stomach irritation?

Taking NSAIDs (nonsteroidal anti-inflammatory drugs) with food is recommended to minimize stomach irritation. These medications can be harsh on the stomach lining and, when ingested without food, can increase the risk of gastrointestinal side effects such as discomfort, ulcers, and bleeding. Consuming NSAIDs with food helps to create a buffer in the stomach, which can reduce direct contact between the drug and the stomach lining, thereby mitigating irritation and promoting better tolerance of the medication.

In contrast, taking NSAIDs on an empty stomach can exacerbate potential side effects, as there is no food to help shield the stomach lining. Drinking water alone may hydrate but does not provide the protective effect food offers against the harsh effects of NSAIDs. Similarly, consuming NSAIDs with citrus juice could potentially lead to increased acidity in the stomach, which may worsen irritation instead of preventing it. Thus, using food as a protective factor is the preferred method when taking these medications to enhance safety and comfort.