What symptom is NOT typically associated with macrolide overdose?

The symptom that is not typically associated with macrolide overdose is elevated heart rate. Macrolides, a class of antibiotics, can produce a range of side effects, some of which involve gastrointestinal disturbances, such as nausea or vomiting, as well as drowsiness. These medications can also potentially cause fever as a reaction. However, an elevated heart rate (tachycardia) is not a common or well-documented symptom directly related to an overdose of macrolides. Instead, tachycardia might be seen in other scenarios or due to different causes, such as infections or anxiety, rather than being a direct result of macrolide toxicity. Thus, identifying elevated heart rate as not typically associated with macrolide overdose is consistent with the expected effects of these drugs when taken in excess.