Which of the following antibiotics can lead to thrombophlebitis as a side effect?

Thrombophlebitis is a condition characterized by inflammation of the vein associated with a blood clot, and it can occur as a side effect of certain antibiotics primarily when they are administered intravenously. Among the options provided, clarithromycin is known for having a higher potential to cause this condition, particularly when given through an IV route.

Clarithromycin is a macrolide antibiotic, which can lead to thrombophlebitis due to its irritant properties on the veins. When antibiotics are infused, particularly those that can irritate veins, the likelihood of this side effect increases.

In contrast, while ceftriaxone, cefepime, and ciprofloxacin can have various side effects, thrombophlebitis is not typically highlighted among them as a common risk associated with their use. Thus, understanding the side effect profile of clarithromycin highlights its potential to cause thrombophlebitis, especially with intravenous administration, making it the correct choice in this context.