Which of the following is a possible adverse reaction of Fluconazole?

Fluconazole is an antifungal medication commonly used to treat various fungal infections. One of the serious adverse reactions associated with its use is Stevens-Johnson syndrome, which is a severe skin reaction that can result in the detachment of the epidermis from the dermis. This condition can manifest as painful rashes, blisters, and can lead to significant complications such as infection or systemic involvement.

Recognizing Stevens-Johnson syndrome as a potential reaction emphasizes the importance of monitoring patients for skin changes, especially in the early stages of treatment. It also highlights the need for clinicians to consider the risk-benefit ratio when prescribing this medication, particularly in patients with a history of skin reactions to medications.

The other choices, while they may be side effects associated with various medications, are either less severe or not commonly documented with Fluconazole. Diarrhea can occur but is generally less alarming than severe skin reactions like Stevens-Johnson syndrome. Hypotension and increased appetite are not typically associated with Fluconazole, making them less relevant in this context.