Which of the following is a First Generation Cephalosporin?

Cefazolin is classified as a First Generation Cephalosporin, which is important for its clinical applications and characteristics. First Generation Cephalosporins are primarily effective against gram-positive bacteria and exhibit some activity against gram-negative bacteria. They are commonly used for prophylaxis in surgical procedures and in the treatment of skin and soft tissue infections, as well as urinary tract infections, due to their ability to penetrate tissues effectively.

In contrast, the other options provided are classified differently. Cefuroxime is a Second Generation Cephalosporin, which has a broader spectrum against gram-negative organisms compared to the first generation. Cefotetan is also a Second Generation Cephalosporin, specifically designed with additional effects against anaerobes and generally used in more diverse infections. Finally, Cefepime is a Fourth Generation Cephalosporin, possessing a wide spectrum of activity against gram-negative bacteria, including Pseudomonas, and is used for more severe infections where broad coverage is necessary.

Understanding these classifications helps in recognizing the different applications and efficacy of various cephalosporins in clinical settings.