Which of the following may indicate toxicity from ASA (Aspirin)?

The presence of tinnitus is often associated with toxicity from aspirin (ASA). This phenomenon occurs because aspirin can influence the auditory pathways in the body, leading to ringing in the ears, which is a classic sign of salicylate toxicity.

When aspirin levels in the body become excessively high, it can cause a variety of symptoms due to its effects on the central nervous system. Tinnitus is particularly notable because it tends to appear specifically in cases of overdose or in patients with prolonged use of aspirin at higher doses; it serves as a warning sign that the concentration of the drug may be reaching levels that are potentially harmful.

While headache, dizziness, and vomiting can all occur in various medical conditions or drug-related issues, they are not as uniquely indicative of aspirin toxicity as tinnitus. Tinnitus is linked more directly and specifically to the pharmacological effects of salicylates, making it a key symptom clinicians look for when assessing for potential toxicity.